Journal
TETRAHEDRON
Volume 70, Issue 35, Pages 5806-5814Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.06.041
Keywords
Spirodioxynaphthalene; Kandelia candel; Mangrove plant; Endophytic fungus; Guignardia sp.
Categories
Funding
- National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
- National High Technology Research and Development Program (863 Program) [2013AA092901, 2012AA092104]
- National Natural Science Foundation of China [31270402, 21172230, 20902094, 41176148, 21002110]
- Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
- Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]
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Six new guignardins A-F (1-6) were isolated from the cultures of endophytic fungus Guignardia sp. KcF8 derived of a mangrove plant Kandelia candel, along with three known analogues, palmarumycins C-1 (7), BG1 (8), and JC1 (9). Compounds 2, 3, 7, and 8 showed antimicrobial activities. Compounds 5-7 exhibited significant cytotoxicities against 10 human tumor cell lines. Compound 3 also displayed significant inhibitory activity against human protein tyrosine phosphatase 1B and histone deacetylase silent information regulator T-1 enzymes, two key targets for the treatment of diabetes. This is the first report on the anti-PTP1B and anti-SIRT1 activities of spirodioxynaphthalenes. (C) 2014 Elsevier Ltd. All rights reserved.
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