Journal
TETRAHEDRON
Volume 70, Issue 4, Pages 832-837Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.12.032
Keywords
Indole alkaloids; Marine sponge; Hyrtios spp.; Hyrtimomines
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Grants-in-Aid for Scientific Research [25670043] Funding Source: KAKEN
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Six new indole alkaloids, hyrtimomines F-K (1-6), were isolated from Okinawan marine sponges Hyrtios spp. The structures of 1-6 were elucidated on the basis of spectroscopic analysis. Hyrtimomine F (1) is a structurally unique bisindole alkaloid possessing an alpha-keto-epsilon-caprolactam ring, while hyrtimomine G (2) is a symmetrical bisindole alkaloid. Hyrtimomines H-K (3-6) are indole alkaloids possessing beta-carboline skeleton with an imidazolium unit. Antimicrobial activities of hyrtimomines F-K (1-6) were evaluated. (C) 2013 Elsevier Ltd. All rights reserved.
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