Journal
TETRAHEDRON
Volume 70, Issue 38, Pages 6728-6732Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.07.075
Keywords
2-Alkynylbenzaldoxime; Tandem reaction; C-H activation; Isoquinoline; Silver triflate
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Funding
- National Natural Science Foundation of China [21302236]
- Fundamental Research Funds for the Central Universities [CDJRC11220001, CQDXWL-2013-023]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry [[2013]693]
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A tandem reaction of 2-alkynylbenzaldoximes with cyclic ethers co-catalyzed by silver(l) triflate and copper(II) acetate is developed, affording 1-substituted isoquinolines in moderate to good yields. The transformation proceeds efficiently through C-H activation. (C) 2014 Elsevier Ltd. All rights reserved.
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