Journal
TETRAHEDRON
Volume 70, Issue 18, Pages 2962-2965Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.03.025
Keywords
22-Membered macrolide; Dinoflagellate; Amphidinium; Cytotoxic activity; Hexahydrofuro[3,2-b]furan
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Funding
- Japan Society for the Promotion of Science [25860079, _501100001691]
- Grants-in-Aid for Scientific Research [25860079] Funding Source: KAKEN
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Iriomoteolide-13a (1) has been isolated from a benthic dinoflagellate Amphidinium sp. (strain KCA09053) as a new 22-membered macrolide containing one hexahydrofuro[3,2-b]furan ring, one tetrahydropyran ring, two tetrahydrofuran rings, three one-carbon branches, and three hydroxyl groups including two hemiketals. The structure of 1 was assigned on the basis of a detailed 2D NMR analysis. Compound 1 exhibited cytotoxic activity against human cervix adenocarcinoma HeLa cells (IC50: 0.5 mu g/mL). (C) 2014 Elsevier Ltd. All rights reserved.
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