4.4 Article

Metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives using K2S2O8

Journal

TETRAHEDRON
Volume 70, Issue 11, Pages 1991-1996

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.01.065

Keywords

Arylphosphination; Oxindole; Difunctionalization; Activated alkenes; Metal-free

Funding

  1. National Natural Science Foundation of China [21072079, 21272100]
  2. Program for New Century Excellent Talents in University [NCET-11-0215]

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A novel metal-free oxidative arylphosphination of activated N-substituted-N-arylacrylamide derivatives by phosphorylation and C H functionalization cascade process has been developed. This methodology provides an efficient way to construct a variety of phosphorus-containing oxindole moieties. (C) 2014 Elsevier Ltd. All rights reserved.

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