Journal
TETRAHEDRON
Volume 69, Issue 23, Pages 4617-4623Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.04.011
Keywords
Anthcolorins; Aspergillus vercicolor; Growth inhibition; Sea urchin; An X-ray crystal-structure analysis; Marine organisms
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [23590028] Funding Source: KAKEN
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Anthcolorins A-F were isolated from a strain of Aspergillus versicolor originally isolated from the sea urchin Anthocidaris crassispana, and their absolute stereostructures were elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, an X-ray crystal-structure analysis and CD spectra. These compounds were unique tetrahydropyrane diterpene type metabolites with oxoindoline at C-3, and some of them exhibited significant growth inhibition against cultured P388 cells. (C) 2013 Elsevier Ltd. All rights reserved.
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