Journal
TETRAHEDRON
Volume 69, Issue 47, Pages 10030-10035Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.09.058
Keywords
Oxindole; Radical; Metal-free; Difunctionalization; Alcohol
Categories
Funding
- National Science Foundation [NSF 21072080, 21272101]
- National Basic Research Program of China (973 Program) [2010CB833203]
- MOE
- [PCSIRT: IRT1138]
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Metal-free synthesis of 3,3-disubstituted oxindoles utilizing N-arylacrylamides and simple alcohols is developed. It provides an efficient method for preparing a series of hydroxyl-containing oxindole derivatives. This reaction is proposed to proceed through oxidative radical cyclization mechanism. The remarkable features of the reaction are metal-free condition and excellent functional group tolerance. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.
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