Journal
TETRAHEDRON
Volume 69, Issue 6, Pages 1712-1716Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.12.037
Keywords
Chemo/regioselectivity; Aza-Michael addition; Heterogeneous catalysis; Polystyrene-supported AlCl3
Categories
Funding
- NSFC [21176213]
- Zhejiang Key Innovation Team of Green Pharmaceutical Technology [2010R50043]
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A simple and efficient procedure is presented for Aza-Michael additions of various amines with conjugate alkenes bearing electron withdrawing group catalyzed by polystyrene-supported aluminum chloride (Ps-AlCl3) without the use of any solvents. The catalyst shows high catalytic activity for both aromatic amines and aliphatic amines. Chemoselective additions of the two types of amines with conjugate alkenes are achieved. Regioselective additions of two different amino groups in one molecule proceed smoothly. Ps-AlCl3 has better recyclability and can be reused several times without apparent loss of activity. (C) 2012 Elsevier Ltd. All rights reserved.
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