Journal
TETRAHEDRON
Volume 69, Issue 37, Pages 8025-8033Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.06.098
Keywords
Indole; Water; Gold-catalysis; Propargylamine; Three component reaction
Categories
Funding
- Greater Nagoya Invitation Program for International Research Scientists in Environmental Science Field
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A simple and efficient route to indole-2-, 3-, or 5-substituted propargylamines by three component-coupling of substituted indole carboxaldehydes, terminal alkyne, and secondary amine in the presence of AuBr3 catalyst in aqueous medium, is described. This protocol provides a concise and effective route toward the synthesis of a variety of indole-2-, 3-, or 5-substituted propargylamines in excellent yields. (C) 2013 Elsevier Ltd. All rights reserved.
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