4.4 Article

New glycosyl-α-aminotetrazole-based catalysts for highly enantioselective aldol reactions

Journal

TETRAHEDRON
Volume 69, Issue 24, Pages 4899-4907

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.04.043

Keywords

alpha-Aminotetrazole; Aldolisation; Carbohydrate; DFT calculation

Funding

  1. Conseil Regional de Picardie
  2. FEDER

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Direct aldol reactions of acetone with aromatic aldehydes have been achieved in high yielding and enantioselective processes using glycosyl-alpha-aminotetrazoles as a new class of organocatalysts. Computational studies at DFT level have been performed to account for the experimental observations. (C) 2013 Elsevier Ltd. All rights reserved.

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