Journal
TETRAHEDRON
Volume 69, Issue 24, Pages 4890-4898Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2013.04.074
Keywords
Lavendamycin; A(3) coupling; Ionic liquid; Quinoline; MCR
Categories
Funding
- DST [SR/S1/OC-70/2008]
- CSIR
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A convergent synthesis of lavendamycin analogues has been accomplished by using A(3) coupling reaction between carboline aldehydes, anilines, and phenylacetylenes. Our approach features the use of the ionic liquids as an environmentally benign solvent medium and synthesis of lavendamycin analogues with diverse substitution pattern. Additionally, the formation of alpha-dihydropyrido-beta-carboline was observed during the reaction of alpha-formyl-beta-carboline, aniline, and ethylpropiolate. (C) 2013 Elsevier Ltd. All rights reserved.
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