Journal
TETRAHEDRON
Volume 68, Issue 44, Pages 9009-9015Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.08.071
Keywords
C-H activation; Enantioselective; Iridium; Heterocycle
Categories
Funding
- 'Molecular Activation Directed towards Straightforward Synthesis,' MEXT, Japan
- Global COE program 'Practical Chemical Wisdom', Waseda University, Japan
Ask authors/readers for more resources
A cationic Ir(I)-tolBINAP complex catalyzed an enantioselective C-C bond formation, which was initiated by secondary sp(3) C-H bond cleavage adjacent to nitrogen atom. A wide variety of 2-(alkylamino) pyridines and alkenes were selectively transformed into the corresponding chiral amines with moderate to almost perfect enantiomeric excesses. Alkynes were also investigated as coupling partners. The effect of alkyl structure in substrates and directing groups were studied. This transformation represents the first example of a highly enantioselective C-H bond activation of a methylene group, not at allylic or benzylic position. (c) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available