Journal
TETRAHEDRON
Volume 68, Issue 21, Pages 3948-3951Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.03.085
Keywords
Aldehyde; Amide; Copper; Homogeneous catalysis; Recycling; Sustainable chemistry
Categories
Funding
- Ministerio de Economia y Competitividad [CSD2007-00006, CTQ2011-24151]
- Generalitat Valenciana (G.V.) [PROMETEO 2009/03]
- University of Alicante
Ask authors/readers for more resources
Copper(II) acetate is a versatile catalyst for the direct transformation of any type of aldehydes into primary amides by stoichiometric reaction with hydroxylamine in water. The catalyst could be recovered 10 times without losing its activity, just by a simple organic layer extraction of the product. The catalyst and the protocol avoid the use of any type of expensive and difficult to handle organic ligand, as well as bases, showing excellent yields, under mild reaction conditions. The great purity of the crude product permits its purification by a simple recrystallization process. The whole protocol fulfils the principle of green chemistry and sustainability, minimizing the use of organic solvents and any type of wastes. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available