Enantioselective total synthesis of eudistomidins G, H, and I

Asymmetric first total synthesis of eudistomidins G, H. and I, tetrahydro-beta-carboline alkaloids from the Okinawan marine tunicate Eudistoma glaucus, has been accomplished with the Bischler-Napieralski reaction and the Noyori catalytic asymmetric hydrogen-transfer reaction. The absolute configurations of eudistomidins G, H, and! were confirmed from comparison of the H-1 and C-13 NMR, and CD spectral data of synthetic and natural eudistomidins G, H, and I, respectively. (C) 2012 Elsevier Ltd. All rights reserved.