Journal
TETRAHEDRON
Volume 68, Issue 10, Pages 2299-2305Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.041
Keywords
Pestalotiopsis sp.; Mangrove-derived fungus; Chlorinated diphenyl ethers; Chlorinated chromones; Xanthones; Antifungal activity
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Funding
- Thailand Research Fund [RTA5480002]
- Royal Golden Jubilee Ph.D. Program of the Thailand Research Fund [PHD/003/2552]
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Prince of Songkla University
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Four new diphenyl ethers, pestalotethers A D (1-4), three new chromones, pestalochromones A-C (5-7), one new xanthone, pestaloxanthone (8), and one new butenolide, pestalolide (9), together with 11 known compounds were isolated from the mangrove-derived fungus Pestalotiopsis sp. PSU-MA69. Their structures were established by spectroscopic techniques. Compounds 1-3 and 5-7 are the rare chlorinated fungal metabolites of diphenyl ethers and chromones, respectively. Pestalolide (9) displayed weak antifungal activity against Candida albicans and Cryptococcus neofonnans. (C) 2012 Elsevier Ltd. All rights reserved.
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