Journal
TETRAHEDRON
Volume 68, Issue 3, Pages 819-829Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.058
Keywords
Premna obtusifolia; Diterpene; Sesquiterpene; Obtusinone A, B, and C; Antibacterial activity; Anti-inflammatory activity
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Funding
- Center for Innovation in Chemistry: (PERCH-CIC), Office of the Higher Education Commission, Ministry of Education
- Songkla University through Crystal Materials Research Unit
- Universiti Sains Malaysia for the Research University [1001/PFIZIK/811160]
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Eleven new diterpenoids: pimaranes (1,2), rosanes (3) abietanes (4-7), icetexanes (8), and rearranged icetexanes (9-11), together with fifteen known diterpenes (12-26) and two known sesquiterpenes (27,28) have been isolated from the roots and twigs of Premna obtusifolia. The structures of these compounds were elucidated on the basis of spectroscopic analysis and X-ray crystallographic data of 8 and 9 were also determined. The antibacterial and anti-inflammatory activities of the isolates were evaluated. (C) 2011 Elsevier Ltd. All rights reserved.
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