Journal
TETRAHEDRON
Volume 68, Issue 39, Pages 8261-8266Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.07.057
Keywords
Neonothopanus nambi; Luminescent mushroom; Aristolane sesquiterpenes; Nambinone; Aurisin; Antimalarial; Cytotoxicity
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Funding
- Thailand Research Fund [DBG5380047]
- Center for Innovation in Chemistry (PERCH-CIC), Ministry of Education, Thailand
- Higher Education Research Promotion and National Research University Project of Thailand, Office of the Higher Education Commission, through the Advanced Functional Materials Cluster of Khon Kaen University
- National Nanotechnology Center
- Mahidol University
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Four new aristolane sesquiterpenes named nambinones A-C (1-3) and 1-epi-nambinone B (4), a new sesquiterpene, nambinone D (5), a known compound, aurisin A (6) as well as a new dimeric sesquiterpene, aurisin K (7), were isolated from two isolates of luminescent mushroom, Neonothopanus nambi, PW1 and PW2. These structures were established on the basis of spectroscopic evidence. The relative configuration of 6 was determined by X-ray crystallographic analysis. Compounds 6 and 7 exhibited antimalarial activity against Plasmodium falciparum and antimycobacterial activity against Mycobacterium tuberculosis. Compounds 3, 6, and 7 showed cytotoxicity against NCl-H187 cancer cell lines. In addition, 6 and 7 showed cytotoxicity against the cholangiocarcinoma cell lines. (C) 2012 Elsevier Ltd. All rights reserved.
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