Journal
TETRAHEDRON
Volume 68, Issue 23, Pages 4434-4437Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.12.068
Keywords
Foldamer; Stabilized alpha-helix; Helix inducer; Hydrogen bond surrogate; Disulfide bridge
Categories
Funding
- National Science Foundation [CHE1027009, CHE-0958457]
- National Institutes of Health [GM073943]
- New York University Department of Chemistry
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [0958457, 1027009] Funding Source: National Science Foundation
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Strategically placed covalent linkages have been shown to stabilize helical conformations in short peptide sequences. Here we report the synthesis of a stabilized alpha-helix that utilizes an internal disulfide linkage. Structural analysis indicates that the dynamic nature of the disulfide bridge allows for the reversible formation of an alpha-helix through oxidation and reduction reactions. (C) 2011 Elsevier Ltd. All rights reserved.
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