Journal
TETRAHEDRON
Volume 68, Issue 16, Pages 3288-3294Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.03.006
Keywords
Strychnos nux-vomica; Indolomonoterpenic alkaloid; Structural elucidation; ECD calculation; Neuroprotective activity
Categories
Funding
- National Science and Technology Project of China [2012ZX09301002-002]
- Natural Science Foundation of China [21132009]
Ask authors/readers for more resources
Eight new trace indolomonoterpenic alkaloids (1-8) were isolated from the seeds of Strychnos nux-vomica. Their structures and absolute configurations were determined by extensive analysis of MS, NMR, CD, and ECD. The skeleton of compound 1 is an unprecedented 6/5/6/5/6/6/7 heptacyclic ring system. Compound 2 possesses a 2-pyridone moiety, and has not yet been found in strychnos alkaloids. Compounds 6 and 7 showed neuroprotective activities on PC12 cells with IE 50 values of 0.68-4.81 mu M and 0.54-6.50 mu M, respectively. The biosynthetic pathway of 1 was also postulated. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available