Journal
TETRAHEDRON
Volume 68, Issue 13, Pages 2851-2857Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.097
Keywords
Marine compounds; Cyclopeptides; Theonella swinhoei; Anti-inflammatory activity
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Funding
- MIUR
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DCCC chromatography followed by HPLC purification on the polar extract of marine sponge Theonella swinhoei resulted in the isolation of five new cyclopeptides, perthamides G-K. The new structures, featuring unprecedented amino acid units, were determined by interpretation of extensive spectroscopic and spectrometric data (MS, H-1 and C-13 NMR, COSY, HSQC, HMBC, and ROESY). Pharmacological analysis demonstrated that these natural cyclopeptides are endowed with anti-inflammatory potential as assessed by their ability to reduce carrageenan-induced mouse paw oedema. (C) 2012 Elsevier Ltd. All rights reserved.
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