Journal
TETRAHEDRON
Volume 68, Issue 10, Pages 2357-2362Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.01.024
Keywords
Artificial receptor; Phosphorylated peptides; CTD peptides; Isothermal titration calorimetry
Categories
Funding
- National Natural Science Foundation of China [20634030, 21104034]
Ask authors/readers for more resources
In this study, a receptor for phosphorylated peptide was developed. The receptor contains Zn2+-dipicolylamine (Zn-Dpa) moiety at one end and guanidiniocarbonyl pyrrole at the other. The association between the receptor and CTD (carboxy-terminal domain of RNA polymerase II) peptides with different phosphorylated patterns was investigated by isothermal titration calorimetry and molecular docking, and the receptor showed much higher affinity towards bis-phosphorylated CTD peptide with affinity constant K=1.09 x 10(5). (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
