Journal
TETRAHEDRON
Volume 68, Issue 39, Pages 8371-8375Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.04.002
Keywords
Probe; NO; Copper complex; Fluorescence imaging
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Funding
- National Natural Science foundation of China [21025102]
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A novel copper(II) complex CuQNE with a naphthalimide-containing ligand was synthesized as a fluorescent sensor of nitric oxide (NO). It featured eightfold fluorescent enhancement toward NO from a dark-background with the detection limit of NO about 1 nM in aqueous solution. The fluorescence response of the CuQNE was specific for NO, the presence of other reactive oxygen species (ROS) and reactive nitrogen species (RNS) did not interfere with the detection of NO in aqueous solution. LC-MS and IR spectra of the reaction mixture both demonstrated that the fluorescence enhancement was possibly attributed to an NO-induced nitrosation of the amino group. Confocal fluorescence images of MCF-7 cells suggested that CuQNE could be applied for monitoring intracellular NO. (C) 2012 Published by Elsevier Ltd.
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