4.4 Article

Total synthesis of (+)-varitriol and (+)-6′-epi-varitriol

Journal

TETRAHEDRON
Volume 68, Issue 5, Pages 1540-1546

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.12.008

Keywords

Corey Chaykovslcy reaction; Epimerization; Cross-metathesis; Wittig reaction

Funding

  1. CSIR, New Delhi
  2. Department of Science & Technology (DST) under SERC FAST [SR/FT/CS-036/2009, GAP-0284]
  3. IICT

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Total synthesis of (+)-varitriol and its C6'-epimer have been achieved starting from commercially available D-()-ribose and o-anisic acid. The key steps involved are Corey Chaykovslcy reaction, triethylamine mediated epimerization, and an olefin cross-metathesis. (C) 2011 Elsevier Ltd. All rights reserved.

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