Journal
TETRAHEDRON
Volume 68, Issue 4, Pages 1286-1298Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.11.035
Keywords
Azanorbornane; Purines; Mitsunobu reaction; Coxsackievirus; Hepatitis C virus; Neuronal nicotinic acetylcholine receptor
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Funding
- Grant Agency of the Czech Republic [202/09/0806]
- Ministry of Education, Youth and Sports of the Czech Republic [1M0508, LC554]
- Gilead Sciences, Inc. (Foster City, CA, U.S.A.)
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Azanorbornylpurine derivatives were prepared by Mitsunobu reaction of appropriate hydroxyazanorbornane derivative with 6-chloropurine or construction of purine base at azanorbornylamines. The prepared target compounds were evaluated for antiviral activity and effect on neuronal and muscle nicotinic acetylcholine receptors. (C) 2011 Published by Elsevier Ltd.
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