Journal
TETRAHEDRON
Volume 68, Issue 39, Pages 8245-8250Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.07.060
Keywords
Penicillium citrinum; Anthraquinone-citrinin derivatives; Antibacterial activity; Antifungal activity
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Funding
- Thailand Research Fund (TRF) [RTA5480002]
- TRF through the Royal Golden Jubilee Ph.D. program [PHD/0231/2551]
- Center of Excellence for Innovation in Chemistry (PERCH-CIC)
- Office of Higher Education Commission
- Prince of Songkla University
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Five new polyketides including two benzopyranones (1 and 2), one isochroman (3) and two anthraquinone-citrinin derivatives (4 and 5) were isolated from the sea fan-derived fungus Penicillium citrinum PSU-F51 together with thirteen known compounds. The structures were determined by spectroscopic methods. The anthraquinone-citrinin derivatives are rare natural products. Compound 4 displayed moderate antibacterial activity against both Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 16 mu g/mL, while the known coniochaetone A displayed moderate antifungal activity against Candida albicans with MIC value of 16 mu g/mL. (C) 2012 Elsevier Ltd. All rights reserved.
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