Journal
TETRAHEDRON
Volume 68, Issue 34, Pages 6941-6947Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2012.05.122
Keywords
-
Categories
Funding
- Ghent University (GOA)
- Research Foundation-Flanders (FWO-Vlaanderen)
- Janssen Research and Development, a Division of Janssen Pharmaceutica NV
Ask authors/readers for more resources
A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization. (C) 2012 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
