Journal
TETRAHEDRON
Volume 67, Issue 40, Pages 7728-7737Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.08.006
Keywords
Vinyl azides; Pyrroles; 1,2,3-Triazoles; 1,3-Dicarbonyl compounds
Categories
Funding
- Nanyang Technological University
- Singapore Ministry of Education, Singapore Ministry of Education, and Science & Engineering Research Council [082 101 0019]
Ask authors/readers for more resources
Tri- and tetrasubstituted N-H pyrroles were prepared by the simple treatment of vinyl azides with 1,3-dicarbonyl compounds in toluene at 100 degrees C via 2H-azirine intermediates generated in situ. When the reactions of vinyl azides and 1,3-dicarbonyl compounds were performed in DMF in the presence of a catalytic amount of K2CO3, 1-vinyl-1,2,3-triazoles were obtained via 1,3-dipolar cycloaddition. These methodologies exploited orthogonal modes of chemical reactivity of vinyl azides, which could be achieved by slight modification of the reaction conditions. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available