Journal
TETRAHEDRON
Volume 67, Issue 35, Pages 6649-6653Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.05.052
Keywords
Endoplasmic reticulum stress suppression; Mushroom; Leccinum extremiorientale; Structural determination
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Leccinine A (1) along with a known compound (2), were isolated from the edible mushroom Leccinum extremiorientale. The structure of 1 was determined by the interpretation of spectral data. Leccinine A showed protective activity against endoplasmic reticulum stress-dependent cell death. Seven analogues (3-9) of 1 were synthesized in order to evaluate the structure-activity relationship, and the result indicated that the formamide group of 1 was indispensable for the activity. (C) 2011 Elsevier Ltd. All rights reserved.
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