Journal
TETRAHEDRON
Volume 67, Issue 44, Pages 8529-8531Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.08.100
Keywords
Papuamide; Melophlus; Depsipeptide; Cytotoxic
Categories
Funding
- NIH [U19 CA67786]
- NCI
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Two known papuamides C (1) and D (2) together with two new depsipeptides, papuamides E (3) and F (4), were isolated from an undescribed sponge of the genus Melophlus collected in the Solomon Islands. The planar structures of the compounds were elucidated on the basis of spectroscopic studies. Papuamides C-F (1-4) showed cytotoxicity against brine shrimp with LD(50) values between 92 and 106 mu g/mL. (C) 2011 Elsevier Ltd. All rights reserved.
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