4.4 Article

Practical synthesis of amides from alkynyl bromides, amines, and water

Journal

TETRAHEDRON
Volume 67, Issue 33, Pages 5920-5927

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.06.045

Keywords

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Funding

  1. National Natural Science Foundation of China [20625205, 20772034, 20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808600]
  3. Ministry of Education of China [20090172110014]
  4. Guangdong Natural Science Foundation [10351064101000000]

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A general and efficient method for the synthesis of a wide range of amides is described here. The reactions were conducted under convenient conditions and provided secondary and tertiary amides in moderate to excellent yields. A variety of amines and substituted alkynyl bromides were used to investigate the scope of the reactions. (C) 2011 Elsevier Ltd. All rights reserved.

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