Journal
TETRAHEDRON
Volume 67, Issue 41, Pages 7983-7988Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.08.024
Keywords
Sinularia; Indonesia; Norcembranoids; Chlorinated metabolite; DFT-calculated C-13 NMR
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Chemical analysis of the Indonesian soft coral Sinularia sp. (order Alcyonacea, family Alcyoniidae) afforded two known and three new C-4 norcembranoids, named chloroscabrolides A (3) and B (4) and prescabrolide (5). Chloroscabrolide A is a pentacyclic norcembranoid including an unprecedented THF-type ring to connect C-13 and C-15; furthermore, it is only the second chlorinated cembranoid derivative to be reported in the literature. The relative configuration of chloroscabrolide A has been established on the basis of a comparison between experimental C-13 NMR data and DFT-calculated C-13 NMR chemical shifts. All the isolated norcembranoids have been evaluated for iNOS protein inhibition. (C) 2011 Elsevier Ltd. All rights reserved.
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