4.4 Article

Total synthesis of (±)-hyrtiazepine

Journal

TETRAHEDRON
Volume 67, Issue 10, Pages 1805-1811

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.01.029

Keywords

Total synthesis; Hyrtiazepine; ortho Selective alpha-hydroxyalkylation

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The total synthesis of the azepinoindole alkaloid, (+/-)-hyrtiazepine, was achieved. Construction of the azepinoindole core structure was carried out by C-4 selective alpha-hydroxyalkylation of 5-hydroxyindole, introduction of serine at C-3 of the indole moiety, and intramolecular imination. (C) 2011 Elsevier Ltd. All rights reserved.

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