Journal
TETRAHEDRON
Volume 67, Issue 37, Pages 7085-7089Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.07.003
Keywords
Coral-associated fungus; Cyclopentapeptides; Polyketides; Aspergillus versicolor; Cladiella sp.
Categories
Funding
- National Basic Research Program of China [2010CB833800]
- National Natural Science Foundation of China [30973680, 30670219]
- PCSIRT [IRT0944]
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Three new cyclopentapeptides, versicoloritides A-C (1-3), a new orcinol tetramer, tetraorcinol A (4), and two new lactones, versicolactones A and B (5 and 6) together with three known metabolites, diorcinol, glyantrypine, and cordyol C were isolated from the fermentation broth of the coral-associated fungus Aspergillus versicolor LCJ-5-4. Their structures were elucidated by spectroscopic and chemical methods. The new compounds 1-4 were evaluated for their radical-scavenging activity and antimicrobial activity against Staphylococcus aureus, Escherichia coli, Enterobacter aerogenes, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans and cytotoxicity against P388 and Hela cell lines. Compound 4 showed weak radical-scavenging activity against the DPPH radical with an IC50 value of 67 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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