Journal
TETRAHEDRON
Volume 67, Issue 40, Pages 7681-7685Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.08.014
Keywords
Macrosphelide; Aza-analogue; RCM strategy; Apoptosis-inducing activity
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Funding
- JST
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Syntheses of 16-membered macrolactams, which were aza-analogues of macrosphelides, could be established effectively by a ring-closing metathesis (RCM) strategy. Novel 19 analogues and six aza-macrosphelide epothilone hybrids were furnished according to simple operations. Biological assay of these artificial aza-macrosphelides revealed that some of them showed stronger apoptosis-inducing activity against human lymphoma cells than the parent compound. (C) 2011 Elsevier Ltd. All rights reserved.
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