Journal
TETRAHEDRON
Volume 67, Issue 20, Pages 3649-3658Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.03.084
Keywords
Sclareol; Spongidines; Pyridines; Marine metabolites; Phospholipase A(2)
Categories
Funding
- MICINN [CTQ2009-11557]
- Junta de Castilla y Leon [GR178, SA063A07]
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Two different strategies for the synthesis of spongidines A and D are presented. Herein we describe a route based in an amino acid insertion followed by aromatization. Another alternative is the construction of a pyridine derivative followed by N-alkylation. Both methodologies have intermediate 5 as a key compound, which is eventually accessible from methyl isoanticopalate. (C) 2011 Elsevier Ltd. All rights reserved.
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