Journal
TETRAHEDRON
Volume 67, Issue 47, Pages 9067-9071Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.09.116
Keywords
Tokaramide A; Cysteine protease inhibitor; Marine sponge; Unusual amino acid; Cathepsin B
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Funding
- Japan Society for the Promotion of Science [21689004]
- Chisso Corporation Fund
- Grants-in-Aid for Scientific Research [21689004] Funding Source: KAKEN
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The first synthesis of tokaramide A (1) is described. Tokaramide A (1) was synthesized via the peptide with a side-chain unprotected arginine residue on Weinreb AM resin by reductive cleavage. (C) 2011 Elsevier Ltd. All rights reserved.
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