Journal
TETRAHEDRON
Volume 67, Issue 32, Pages 5725-5731Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.06.027
Keywords
Solvent-free; delta-Carbolines; Carbazoles; Cadogen cyclization; DPPE
Categories
Funding
- National Science and Technology Major Project 'Key New Drug Creation and Manufacturing Program', China [2009ZX09301-001]
- National Natural Science Foundation of China [21072205]
- Shanghai Municipality Science and Technology [09JC1416600, 09ZR1437900]
Ask authors/readers for more resources
A green and efficient preparation of functionalized delta-carbolines/carbazoles via reductive ring closure by 1,2-bis(dipenylphosphino)ethane under solvent-free conditions is described. The starting materials 3-nitro-2-phenylpyridines/2-nitrobiphenyl derivatives are readily prepared through Suzuki-Miyaura cross-coupling reaction from commercially available compounds. And the polar by-product ethane-1,2-diylbis(diphenylphosphine oxide) is easily removed from the relatively polar reaction mixture. Various substituted delta-carbolines/carbazoles are obtained in acceptable yields. It is particularly worth mentioning that substrates with electron-withdrawing groups (EWG) also give the desired products in good yield. (C) 2011 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available