4.4 Article

One-pot synthesis of 5-sulfonamidopyrazole from terminal alkynes, sulfonyl azides and hydrozones

Journal

TETRAHEDRON
Volume 67, Issue 42, Pages 8086-8091

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.08.067

Keywords

Multicomponent reactions; Alkynes; Sulfonyl azides; Hydrozones; Pyrazoles; Electrocyclic reactions

Funding

  1. National Nature Science Foundation of China [21032005, 20872128]

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5-Sulfonamidopyrazoles were efficiently synthesized from terminal alkynes, sulfonyl azides and hydrozones. The sequential reaction involves a copper-catalyzed three-component reaction, a Lewis acid-catalyzed electrocyclic reaction and a dehydrogenation. (C) 2011 Elsevier Ltd. All rights reserved.

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