Journal
TETRAHEDRON
Volume 67, Issue 14, Pages 2644-2650Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2011.02.005
Keywords
Stereoselective synthesis; 3-(Aminomethylene)-2-oxindoles; Hesperadin; Ugi-4MCR; Domino Heck/Buchwald reaction
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Funding
- Iran National Science Foundation (INSF)
- Kimia Exir Company
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Potentially bioactive 3-(anilinoarylmethylene)-2-oxindoles as Hesperadin analogoues have been synthesized via a two-step procedure: (a) an Ugi-4MCR and (b) reaction of the Ugi adduct with aniline in the presence of a palladium catalyst via domino Heck/Buchwald reaction. In all cases, a single isomer with the Z-configuration was obtained in good to high yields. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.
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