Journal
TETRAHEDRON
Volume 66, Issue 21, Pages 3730-3735Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.03.065
Keywords
Copper; Copper-based nanoparticles; Heterocycles; N-Arylation; Microwave heating; Poly(ethylene glycol)
Categories
Funding
- CNRS
- Ligue Contre le Cancer
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A mild, simple and efficient microwave-enhanced copper-catalyzed protocol for N-arylation using high molecular weight poly(ethylene glycol) (PEG(3400)) as a solvent is reported. Indole and benzimidazole have been N-arylated in the presence of cuprous oxide, cesium carbonate, and PEG(3400), under microwave activation, with no supplementary ligands. Simple treatment by precipitation in Et2O and filtration provided the expected product after evaporation and recovery of the catalytic system as a precipitate. The recovery and one successful re-use of the catalytic system is also described. The formation of copper-based nanoparticles was demonstrated by TEM analysis. (C) 2010 Elsevier Ltd. All rights reserved.
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