Journal
TETRAHEDRON
Volume 66, Issue 47, Pages 9194-9202Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.09.067
Keywords
Cyanobacteria; Microcystis; Micropeptins; Anabaenopeptins; Natural products
Categories
Funding
- Israel Science Foundation [776/06]
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Eight new secondary metabolites micropeptin MM836 (1) micropeptin MM850 (2) micropeptin MM916 (3) micropeptin MM932 (4) micropeptin MM978 (5) anabaenopeptin MM823 (6) anabaenopeptin MM850 (7) and anabaenopeptin MM913 (8) as well as the known anabaenopeptin B (9) were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp that was collected from a fishpond in Kibbutz Ma agan Michael Israel in September 2006 The structure of the pure natural products was established by spectroscopic methods including 1D and 2D NMR, UV and MS techniques The absolute configuration of the chiral centers of the compounds was determined using Marfey s method The inhibitory activity of the compounds was determined against the serine proteases trypsin chymotrypsin thrombin and elastase (C) 2010 Elsevier Ltd All rights reserved
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