Journal
TETRAHEDRON
Volume 66, Issue 46, Pages 8928-8932Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.09.044
Keywords
Primary amine thiourea; Michael reactions; Isobutylaldehyde; Maleimides; Enantioselective
Categories
Funding
- National Natural Science Foundation of China [20802075]
- Chinese Academy of Sciences
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Chiral primary amine thiourea catalysts were first successfully applied to promote Michael addition of isobutyraldehyde to maleimides. A variety of N-aryl and N-aliphatic maleimides provided Michael adducts in excellent yields (up to 98%) and enantioselectivities (up to 99% ee) with 5 mol % catalyst. (C) 2010 Elsevier Ltd. All rights reserved.
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