Journal
TETRAHEDRON
Volume 66, Issue 15, Pages 2855-2862Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.02.041
Keywords
-
Categories
Funding
- NCI Open Repository Program
- EPSRC National Mass Spectrometric Centre
- University of Wales, Swansea, UK
- Egyptian Government for a Ph.D. scholarship
- BBSRC Research Development Fellowship
Ask authors/readers for more resources
We report here on the discovery and structure determination of three new diastereomeric pairs of cyclic ether acetogenins, laurefurenynes A-F, isolated from the aqueous extract of the alga Laurencia sp. collected in the Philippines. Extensive use was made of NMR spectroscopic data and high resolution MS to determine the structures of the pure compounds. The most stable and the lowest energy conformation was determined using molecular modelling, and their cytotoxic activity was tested against different tumour cells, a significant indication that laurefurenyne C and F are moderately cytotoxic, but nonselective whilst the others are inactive. (C) 2010 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available