Coupling/cyclization of 1,6-enynes with aryl halides: an efficient and general route for the synthesis of functionalized hexahydroindole and hexahydrobenzofuran derivatives

An efficient and general route for the synthesis of functionalized hexahydroindole and hexahydrobenzofuran derivatives has been developed via the palladium-catalyzed domino coupling/cyclization reaction of 1,6-enynes and aryl halides. The results indicated that the electronic properties of the aryl halides strongly affect the reaction yields. (C) 2010 Elsevier Ltd. All rights reserved.