4.4 Article

DMAP-catalyzed cascade reaction: one-pot synthesis of benzofurans in water

Journal

TETRAHEDRON
Volume 66, Issue 50, Pages 9629-9633

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.09.095

Keywords

Benzofuran; Cascade reaction; Dimethylaminopyridine; Halogenated ketones; Salicylaldehydes

Funding

  1. National Natural Science Foundation of China [20872001, 20802002]
  2. Education Commission of Anhui Province [TD200707]

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A series of benzofurans were efficiently synthesized in good to excellent yields using 4-dimethylaminopyridine (DMAP) catalyzed cascade reaction between salicylaldehydes and halogenated ketones in water at 80 degrees C opened atmosphere. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.

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