Journal
TETRAHEDRON
Volume 66, Issue 32, Pages 6008-6012Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.06.023
Keywords
Makassaric acid; Subersic acid; Meroterpenoids; Protein kinase inhibitors; Barton/McCombie
Categories
Funding
- Junta de Castilla y Leon [GR178, SA063A07]
- MICINN [011200911557]
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Description of the first synthesis of (+)-makassaric acid, an important kinase MK2 inhibitor. The key step was a Barton/McCombie radical deoxygenation. (c) 2010 Elsevier Ltd. All rights reserved.
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