Journal
TETRAHEDRON
Volume 66, Issue 42, Pages 8325-8334Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.07.016
Keywords
Task specific ionic liquids; Onium salts supported organic synthesis; Peptides
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Task specific ionic liquids and onium salts have been used as soluble supports for peptide synthesis. These new supports combine easy monitoring, high loading capacities, large scale preparation, and homogeneous kinetics characteristics while keeping advantages of solid-phase synthesis including easy purification and workup. Careful structural design of these supports allowed for fine tuning of physical properties leading to better yields, kinetics, and purities. (C) 2010 Published by Elsevier Ltd.
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