Journal
TETRAHEDRON
Volume 66, Issue 23, Pages 4040-4042Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.04.028
Keywords
3,4-Dihydropyrimidine-2(1H)one; Multicomponent reaction; One-pot; Urea; Diketene
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Funding
- Research Council of Shahid Beheshti University
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5-Carboxamide substituted 3,4-dihydropyrimidine-2(1H)one derivatives were synthesized in a simple and efficient method from the one-pot four-component reactions of an aliphatic or aromatic amine, diketene, an aromatic aldehyde and urea or thiourea in the presence of p-toluenesulfonic acid as a catalyst under mild reaction conditions at ambient temperature. (C) 2010 Elsevier Ltd. All rights reserved.
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