4.4 Article

Catalyst free conjugate addition of indoles and pyrroles to nitro alkenes under solvent free condition (SFC): an effective greener route to access 3-(2-nitro-1-phenylethyl)-1H-indole and 2-(2-nitro-1-phenylethyl)-1H-pyrrole derivatives

Journal

TETRAHEDRON
Volume 66, Issue 34, Pages 7050-7056

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.05.104

Keywords

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Funding

  1. National Science Council of the Republic of China
  2. National Taiwan Normal University

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Catalyst free conjugate addition of reactive hetero aromatics (pyrrole and indoles) to nitro alkenes under solvent free condition is described. This method provides several advantages, such as operational simplicity, solvent-free conditions and good yields of products. Also it is environmentally friendly and more cost effective alternative to existing protocols. (C) 2010 Elsevier Ltd. All rights reserved.

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