Journal
TETRAHEDRON
Volume 66, Issue 27-28, Pages 5065-5070Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.04.118
Keywords
Daphnane-type diterpenoid; Trigochinins D-I; Absolute configuration; Cytotoxic activity
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Funding
- National Natural Science Foundation of China [30630072, 30721005, 20932007]
- National Science 82 Technology Major Project 'Key New Drug Creation and Manufacturing Program' of China [2009ZX09301-001]
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Six new highly oxygenated daphnane-type diterpenoids, trigochinins D-I (1-6), were isolated from the twigs and leaves of Trigonostemon chinensis. Their structures with the absolute configuration were established on the basis of spectroscopic method and CD analysis. Trigochinins D-F (1-3) possessed a rare 4,6-oxetane moiety in this compound class. Trigochinins E and F exhibited significant inhibiting activity against HL-60 tumor cell line. (C) 2010 Elsevier Ltd. All rights reserved.
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